The present manuscript describes simple, sensitive, rapid, accurate, precise and economical Q-absorbance ratio method for the simultaneous determination of chlorzoxazone and paracetamol in tablet dosage form. Absorbance ratio method uses the ratio of absorbance at two selected wavelengths, one of which is an isoabsorptive point and other being the λ-max of one of the two components. Chlorzoxazone and paracetamol shows an isoabsorptive point at 269.40 nm in distilled water. The second wavelength used is 280 nm, which is the λ-max of chlorzoxazone in distilled water. The linearity was obtained in the concentration range of 5-40 μg/ml for both chlorzoxazone and paracetamol. The concentrations of the drugs were determined by using ratio of absorbance at isoabsorptive point and at the λ-max of chlorzoxazone. The method was successfully applied for the determination of these two drugs in tablet dosage form. No interference was observed from excipients present in the tablet. The suitability of this method for the quantitative determination of chlorzoxazone and paracetamol was proved by validation. The proposed method was found to be simple and sensitive for the routine analysis of these two drugs in tablet dosage form. The results of analysis have been validated statistically and by recovery studies.
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